HitPredict

Interactor 1: MED1 (Q15648)
Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
Gene: MED1

Interactor 2: MD13L (Q71F56)
Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)
Gene: MED13L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	28514442, 24981860, 33961781, 23322298, 36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0016592 - mediator complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1581 Hs			1 2210
+	Hs
		1076213 MED1_HUMAN (1-1581): 0: 1281: 100.00		MED13_HUMAN (4-2210): 0: 3181: 51.34
+	Hs
		1154041 NIPBL_HUMAN (984-1563): 7.42e-16: 86.1: 16.01		MD13L_HUMAN (1-2210): 0: 3763: 100.00
+	Hs
		1154083 NIPBL_HUMAN (984-1563): 7.42e-16: 86.1: 16.01		MED13_HUMAN (4-2210): 0: 3181: 51.34
+	Dm
		1182301 MED1_DROME (8-1446): 3.39e-45: 181: 18.40		MED13_DROME (943-1152): 8.63e-10: 66.7: 23.77