HitPredict

Interactor 1: MED1 (Q15648)
Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
Gene: MED1

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25720964, 23322298
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0016567 - protein ubiquitination
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1581 Hs			1 707
+	Hs
		1281391 PRR36_HUMAN (932-1579): 1.77e-17: 91.3: 11.67		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Dm
		1370339 Q9VLS7_DROME (558-1479): 2.66e-10: 67.8: 9.81		FBXW7_DROME (142-705): 3.41e-131: 421: 66.33
+	Mm
		903669 KMT2C_MOUSE (1008-1567): 1.2e-17: 92.1: 10.12		WDR5_MOUSE (570-706): 2.64e-27: 115: 23.02
+	Hs
		903576 RERE_HUMAN (997-1464): 1.82e-14: 81.5: 16.56		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		903374 KMT2C_HUMAN (1092-1565): 3.68e-11: 70.9: 12.71		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		1329253 TARA_HUMAN (740-1572): 1.05e-11: 72.3: 11.98		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00