HitPredict

Interactor 1: IKBB (Q15653)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Gene: NFKBIB

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	10497169, 25900982, 10514424
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0043122 - regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 356 Hs			1 605
+	Mm
		1112906 IKBB_MOUSE (1-355): 1.52e-80: 251: 83.52		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		639829 IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		961451 NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Mm
		1112935 IKBA_MOUSE (7-335): 8.92e-77: 240: 31.07		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Mm
		1112931 NFKB2_MOUSE (55-347): 8.38e-68: 230: 33.11		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Mm
		222603 IKBE_MOUSE (51-333): 1.19e-64: 211: 32.86		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		121606 IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1076395 IKBB_HUMAN (1-356): 9.91e-80: 249: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		639819 IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Mm
		1131318 IKBA_MOUSE (7-335): 8.92e-77: 240: 31.07		FBW1B_MOUSE (96-605): 2.25e-143: 428: 85.69
+	Hs
		961443 NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		121601 IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1349608 RAI14_HUMAN (94-266): 8.7e-11: 65.5: 27.17		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		862124 DAPK1_HUMAN (1-260): 1.41e-48: 177: 22.22		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		639784 IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		961417 NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		166894 ANR28_HUMAN (6-181): 6.32e-24: 105: 22.60		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		121550 IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72		PRP4_HUMAN (387-594): 6.19e-35: 140: 23.66
+	Hs
		1281440 RAI14_HUMAN (94-266): 8.7e-11: 65.5: 27.17		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		595684 BCL3_HUMAN (49-151): 2.25e-12: 69.8: 28.16		TBL1R_HUMAN (501-605): 3.85e-15: 80.4: 16.67