HitPredict

Interactor 1: IKBB (Q15653)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Gene: NFKBIB

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	33961781, 11485410, 21862596, 14743216
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~CC2-LZ
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 356 Hs			1 419
+	Mm
		291802 IKBB_MOUSE (1-355): 1.52e-80: 251: 83.52		NEMO_MOUSE (1-419): 3e-53: 184: 86.64
+	Bt
		1259265 Q8WNW7_BOVIN (14-335): 8.63e-77: 240: 30.82		NEMO_BOVIN (1-419): 5.25e-56: 192: 85.68
+	Hs
		639834 IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Mm
		291826 IKBA_MOUSE (7-335): 8.92e-77: 240: 31.07		NEMO_MOUSE (1-419): 3e-53: 184: 86.64
+	Hs
		961453 NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		121608 IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		862142 DAPK1_HUMAN (1-260): 1.41e-48: 177: 22.22		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		551718 IKBB_HUMAN (1-356): 9.91e-80: 249: 100.00		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		551669 NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		1216417 TNKS2_HUMAN (62-347): 1.71e-50: 183: 17.73		MY18B_HUMAN (35-415): 6.59e-31: 127: 13.46
+	Hs
		724779 NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		862127 DAPK1_HUMAN (1-260): 1.41e-48: 177: 22.22		MYO5B_HUMAN (64-394): 2.99e-18: 89.7: 16.95
+	Hs
		965180 ANK2_HUMAN (159-346): 4.02e-39: 150: 17.55		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		587763 NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		724782 ANK2_HUMAN (159-346): 4.02e-39: 150: 17.55		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		725139 ANK2_HUMAN (159-346): 4.02e-39: 150: 17.55		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		1219814 ANKH1_HUMAN (6-91): 2.81e-10: 63.8: 16.28		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		1078921 RAI14_HUMAN (94-266): 8.7e-11: 65.5: 27.17		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		725049 RAI14_HUMAN (94-266): 8.7e-11: 65.5: 27.17		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		1268104 RAI14_HUMAN (94-266): 8.7e-11: 65.5: 27.17		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89