HitPredict

Interactor 1: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1732
+	Hs
		915741 RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		1076834 RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		916101 RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		148297 RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		148632 RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		148653 RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Mm
		823530 RAC1_MOUSE (2-191): 2.63e-75: 226: 39.09		CTRO_MOUSE (4-1025): 1.07e-120: 424: 23.41
+	Hs
		681775 RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		916061 RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Mm
		925783 RAC1_MOUSE (2-191): 2.63e-75: 226: 39.09		TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88
+	Dm
		116376 RHO1_DROME (6-180): 2.06e-79: 236: 41.76		M9PI41_DROME (339-1478): 1.41e-80: 297: 13.08
+	Hs
		254483 RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		1035174 RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		254433 RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		254467 RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		436290 RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		915655 RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Dm
		816384 RHO1_DROME (6-180): 2.06e-79: 236: 41.76		Q961D4_DROME (391-1130): 1.08e-21: 105: 12.02
+	Dm
		816395 RHO1_DROME (6-180): 2.06e-79: 236: 41.76		X2JE40_DROME (391-1052): 3.22e-21: 103: 12.56
+	Hs
		254468 RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07