HitPredict

Interactor 1: PTN14 (Q15678)
Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)
Gene: PTPN14

Interactor 2: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	27432908, 28675297, 22948661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1187 Hs			1 1192
+	Hs
		1087899 PTN21_HUMAN (1-1187): 0: 817: 52.29		WWC2_HUMAN (1-1192): 0: 1008: 100.00
+	Hs
		1076894 PTN14_HUMAN (1-1187): 0: 985: 100.00		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		1087910 PTN21_HUMAN (1-1187): 0: 817: 52.29		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		299270 FARP2_HUMAN (14-523): 3.59e-140: 453: 21.60		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		1220100 E41L3_HUMAN (13-857): 2.64e-133: 435: 16.82		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		1076909 PTN14_HUMAN (1-1187): 0: 985: 100.00		MAGI1_HUMAN (1-300): 2.32e-62: 236: 18.94
+	Dm
		1359212 Q9V3V3_DROME (1-1187): 1.34e-173: 547: 24.75		KIBRA_DROME (8-1190): 0: 661: 30.31
+	Hs
		1076933 PTN14_HUMAN (1-1187): 0: 985: 100.00		WWOX_HUMAN (5-198): 5.51e-47: 176: 21.11
+	Hs
		1076918 PTN14_HUMAN (1-1187): 0: 985: 100.00		WWP1_HUMAN (6-136): 2.07e-35: 148: 23.78
+	Hs
		1076872 PTN14_HUMAN (1-1187): 0: 985: 100.00		MAGI3_HUMAN (9-97): 1.18e-34: 146: 43.82
+	Hs
		125485 PTN14_HUMAN (1-1187): 0: 985: 100.00		WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84
+	Hs
		1076920 PTN14_HUMAN (1-1187): 0: 985: 100.00		SAV1_HUMAN (4-88): 3.52e-27: 117: 38.82
+	Hs
		808641 PTN14_HUMAN (1-1187): 0: 985: 100.00		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		1087931 PTN21_HUMAN (1-1187): 0: 817: 52.29		WWP1_HUMAN (6-136): 2.07e-35: 148: 23.78
+	Hs
		808660 PTN21_HUMAN (1-1187): 0: 817: 52.29		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Dm
		1359218 Q9V3V3_DROME (1-1187): 1.34e-173: 547: 24.75		SUDX_DROME (3-302): 8.76e-48: 187: 20.07
+	Hs
		1032023 PTPRS_HUMAN (555-1181): 7.32e-124: 423: 20.81		SYT11_HUMAN (625-963): 1.48e-88: 295: 12.18
+	Hs
		490015 PTPRF_HUMAN (364-1179): 1.6e-116: 401: 15.88		SYT11_HUMAN (625-963): 1.48e-88: 295: 12.18
+	Hs
		616920 PTPRB_HUMAN (597-1186): 2.37e-136: 459: 22.78		MAGI3_HUMAN (9-97): 1.18e-34: 146: 43.82
+	Hs
		1336123 E41L3_HUMAN (13-857): 2.64e-133: 435: 16.82		SMUF1_HUMAN (40-194): 1.56e-14: 80.8: 16.49