HitPredict

Interactor 1: MARE1 (Q15691)
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)
Gene: MAPRE1

Interactor 2: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	18477699, 19696028
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0051233 - spindle midzone GO:0097431 - mitotic spindle pole
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 268 Hs			1 344
+	Hs
		568676 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18
+	Hs
		160586 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		610730 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		KAPCB_HUMAN (36-342): 2.47e-133: 385: 26.50
+	Hs
		1292303 MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		160861 MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		1075070 MARE2_HUMAN (1-267): 3.67e-121: 350: 55.16		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		160581 MARE2_HUMAN (1-267): 3.67e-121: 350: 55.16		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Sc
		758784 BIM1_YEAST (16-257): 3.5e-85: 259: 32.63		IPL1_YEAST (9-330): 1.16e-79: 249: 41.95