HitPredict

Interactor 1: MARE1 (Q15691)
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)
Gene: MAPRE1

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.948

Property	Details
Experiments	23001180, 26186194, 28514442, 34079125, 33961781, 35271311
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CH~CH, CH~EF-hand_7, CH~Spectrin
Common GO terms	GO:0003723 - RNA binding GO:0005794 - Golgi apparatus GO:0005874 - microtubule GO:0045296 - cadherin binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 268 Hs			1 7388
+	Hs
		1357665 MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Mm
		1142238 MARE1_MOUSE (1-257): 1.2e-149: 420: 96.89		MACF1_MOUSE (1-7388): 0: 2164: 83.39
+	Dm
		54305 Q9XZ57_DROME (1-265): 4e-126: 361: 52.60		A1Z9J2_DROME (187-1555): 1.31e-72: 276: 23.30
+	Hs
		1068538 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		551719 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		3527 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		A0A0U1RQJ2_HUMAN (277-1523): 7.08e-13: 78.6: 9.81
+	Hs
		974082 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		963333 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		297830 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		K0754_HUMAN (757-1741): 1.73e-10: 70.9: 10.05
+	Hs
		521551 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		1045422 MARE1_HUMAN (1-257): 3.32e-150: 421: 100.00		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		974173 MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		1045564 MARE3_HUMAN (1-268): 1.91e-134: 382: 63.70		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39