HitPredict

Interactor 1: T22D1 (Q15714)
TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)
Gene: TSC22D1

Interactor 2: WNK1 (Q9H4A3)
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)
Gene: WNK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	20936779
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1073 Hs			1 2382
+	Hs
		1330751 T22D4_HUMAN (817-1056): 3.61e-23: 105: 34.15		WNK1_HUMAN (1-2382): 0: 877: 100.00
+	Hs
		161716 GAK_HUMAN (455-793): 2.95e-10: 66.9: 18.82		WNK1_HUMAN (1-2382): 0: 877: 100.00
+	Hs
		1377724 T22D4_HUMAN (817-1056): 3.61e-23: 105: 34.15		WNK2_HUMAN (128-2196): 8.79e-129: 455: 26.11
+	Hs
		1356429 PCLO_HUMAN (2-1014): 2.52e-26: 119: 8.24		TNIK_HUMAN (198-1222): 4.7e-123: 427: 13.42
+	Rn
		506773 PCLO_RAT (368-1058): 4.58e-24: 112: 9.80		KCC2A_RAT (219-633): 4.07e-124: 402: 18.96
+	Hs
		1025245 T22D4_HUMAN (817-1056): 3.61e-23: 105: 34.15		AAPK1_HUMAN (195-737): 1.29e-123: 404: 16.40
+	Hs
		99455 GAK_HUMAN (455-793): 2.95e-10: 66.9: 18.82		F5GWT4_HUMAN (1-2133): 4.33e-103: 372: 41.88
+	Hs
		1077348 T22D1_HUMAN (1-1073): 7.61e-82: 291: 100.00		NRBP2_HUMAN (218-476): 2.3e-28: 124: 31.41
+	Hs
		1077357 T22D1_HUMAN (1-1073): 7.61e-82: 291: 100.00		NRBP_HUMAN (234-476): 4.38e-26: 117: 34.26
+	Hs
		1317207 T22D4_HUMAN (817-1056): 3.61e-23: 105: 34.15		WNK3_HUMAN (1397-2378): 2.71e-57: 222: 18.10
+	Hs
		256827 T22D2_HUMAN (230-642): 1.86e-10: 67.3: 10.41		WNK3_HUMAN (1397-2378): 2.71e-57: 222: 18.10
+	Hs
		161708 GAK_HUMAN (455-793): 2.95e-10: 66.9: 18.82		WNK3_HUMAN (1397-2378): 2.71e-57: 222: 18.10
+	Hs
		1345645 T22D4_HUMAN (817-1056): 3.61e-23: 105: 34.15		NRBP2_HUMAN (218-476): 2.3e-28: 124: 31.41
+	Hs
		1304681 T22D3_HUMAN (959-1060): 8.88e-24: 99.9: 67.96		NRBP2_HUMAN (218-476): 2.3e-28: 124: 31.41
+	Hs
		1355633 T22D4_HUMAN (817-1056): 3.61e-23: 105: 34.15		NRBP_HUMAN (234-476): 4.38e-26: 117: 34.26
+	Dm
		1098027 BUN2_DROME (970-1059): 3.36e-19: 96.2: 62.22		NRBP_DROME (126-481): 4.26e-27: 121: 29.58
+	Hs
		1304682 T22D3_HUMAN (959-1060): 8.88e-24: 99.9: 67.96		NRBP_HUMAN (234-476): 4.38e-26: 117: 34.26
+	Hs
		256831 T22D2_HUMAN (230-642): 1.86e-10: 67.3: 10.41		NRBP2_HUMAN (218-476): 2.3e-28: 124: 31.41
+	Hs
		256836 T22D2_HUMAN (230-642): 1.86e-10: 67.3: 10.41		NRBP_HUMAN (234-476): 4.38e-26: 117: 34.26
+	Dm
		113976 M9PB30_DROME (2-390): 5.96e-11: 69.3: 8.42		M9PB30_DROME (1751-2377): 7.51e-15: 83.8: 10.79