HitPredict

Interactor 1: HERC1 (Q15751)
Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)
Gene: HERC1

Interactor 2: TRI67 (Q6ZTA4)
Tripartite motif-containing protein 67 (TRIM9-like protein)
Gene: TRIM67

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36215168
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SPRY~SPRY, WD40~fn3
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 4861 Hs			1 783
+	Hs
		1171774 SMUF2_HUMAN (4334-4843): 2.33e-164: 530: 23.60		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		1171800 SMUF1_HUMAN (4320-4843): 8.67e-163: 526: 22.58		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		808169 NEDD4_HUMAN (4360-4841): 3.39e-153: 517: 20.97		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		1171253 ITCH_HUMAN (4369-4843): 2.48e-157: 516: 23.03		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		1171305 NED4L_HUMAN (4355-4841): 1.54e-156: 516: 19.68		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		1170603 HUWE1_HUMAN (4372-4842): 8.91e-133: 474: 21.86		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		983166 UBE3A_HUMAN (4457-4842): 3.46e-126: 424: 25.96		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		983266 UBE3A_HUMAN (4457-4842): 3.46e-126: 424: 25.96		TRIM1_HUMAN (107-779): 9.11e-128: 400: 23.32
+	Hs
		1133223 HECD3_HUMAN (4504-4843): 2.79e-52: 203: 36.72		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Mm
		1186495 HUWE1_MOUSE (4372-4842): 5.86e-133: 475: 21.86		TRIM3_MOUSE (190-767): 6.68e-78: 268: 14.85
+	Hs
		262198 HECW2_HUMAN (4408-4843): 6.03e-133: 463: 24.50		TRIM3_HUMAN (190-767): 1.26e-78: 270: 15.01
+	Hs
		1125817 HERC4_HUMAN (4513-4836): 5.31e-12: 75.1: 24.77		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Hs
		319890 HERC2_HUMAN (593-845): 9.55e-10: 67.8: 15.81		TRI67_HUMAN (1-783): 0: 593: 100.00
+	Mm
		1118130 HERC2_MOUSE (593-845): 2.93e-09: 66.3: 16.21		TRI67_MOUSE (1-783): 0: 574: 89.40
+	Hs
		1290890 SMUF1_HUMAN (4320-4843): 8.67e-163: 526: 22.58		TRI11_HUMAN (1-121): 1.6e-09: 63.2: 20.66
+	Hs
		125454 WWP2_HUMAN (4369-4843): 4.38e-156: 511: 21.36		TRI25_HUMAN (1-158): 8.85e-09: 60.9: 13.29
+	Hs
		1052695 HUWE1_HUMAN (4372-4842): 8.91e-133: 474: 21.86		TRI25_HUMAN (1-158): 8.85e-09: 60.9: 13.29
+	Hs
		1052789 HECW2_HUMAN (4408-4843): 6.03e-133: 463: 24.50		TRI25_HUMAN (1-158): 8.85e-09: 60.9: 13.29
+	Hs
		1049030 HERC3_HUMAN (602-747): 3.17e-10: 68.9: 30.82		TRI14_HUMAN (301-760): 3.67e-71: 241: 17.80