HitPredict

Interactor 1: RUNX1 (G5EFQ5)
Runt-related transcription factor rnt-1
Gene: rnt-1

Interactor 2: SMA4 (P45897)
Dwarfin sma-4 (MAD protein homolog 3)
Gene: sma-4

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15385167
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0006357 - regulation of transcription by RNA polymerase II GO:0045138 - nematode male tail tip morphogenesis
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 301 Ce			1 570
+	Hs
		1047428 RUNX2_HUMAN (6-191): 1.03e-89: 278: 42.86		SMAD5_HUMAN (152-569): 4.91e-168: 487: 31.32
+	Mm
		936606 RUNX2_MOUSE (6-191): 1.29e-91: 285: 42.86		SMAD1_MOUSE (152-569): 1.12e-162: 473: 30.83
+	Hs
		1047413 RUNX2_HUMAN (6-191): 1.03e-89: 278: 42.86		SMAD1_HUMAN (152-569): 7.32e-162: 471: 30.83
+	Hs
		950176 RUNX2_HUMAN (6-191): 1.03e-89: 278: 42.86		SMAD3_HUMAN (151-569): 4.84e-158: 460: 31.84
+	Hs
		1047412 RUNX2_HUMAN (6-191): 1.03e-89: 278: 42.86		SMAD2_HUMAN (151-569): 4.6e-153: 448: 28.89
+	Hs
		1045140 RUNX3_HUMAN (7-184): 1.95e-73: 233: 42.70		SMAD5_HUMAN (152-569): 4.91e-168: 487: 31.32
+	Hs
		964412 RUNX1_HUMAN (9-191): 4.08e-71: 228: 37.17		SMAD5_HUMAN (152-569): 4.91e-168: 487: 31.32
+	Hs
		1045124 RUNX3_HUMAN (7-184): 1.95e-73: 233: 42.70		SMAD1_HUMAN (152-569): 7.32e-162: 471: 30.83
+	Hs
		964344 RUNX1_HUMAN (9-191): 4.08e-71: 228: 37.17		SMAD1_HUMAN (152-569): 7.32e-162: 471: 30.83
+	Hs
		950174 RUNX3_HUMAN (7-184): 1.95e-73: 233: 42.70		SMAD3_HUMAN (151-569): 4.84e-158: 460: 31.84
+	Hs
		950144 RUNX1_HUMAN (9-191): 4.08e-71: 228: 37.17		SMAD3_HUMAN (151-569): 4.84e-158: 460: 31.84
+	Hs
		1045123 RUNX3_HUMAN (7-184): 1.95e-73: 233: 42.70		SMAD2_HUMAN (151-569): 4.6e-153: 448: 28.89
+	Mm
		1112966 Q3UM65_MOUSE (9-191): 5.46e-71: 228: 37.17		SMAD2_MOUSE (151-569): 7.42e-154: 451: 28.89
+	Hs
		964343 RUNX1_HUMAN (9-191): 4.08e-71: 228: 37.17		SMAD2_HUMAN (151-569): 4.6e-153: 448: 28.89
+	Mm
		192366 RUNX2_MOUSE (6-191): 1.29e-91: 285: 42.86		SMAD6_MOUSE (109-552): 2.34e-126: 381: 24.40
+	Hs
		206960 RUNX2_HUMAN (6-191): 1.03e-89: 278: 42.86		SMAD6_HUMAN (109-553): 1.6e-123: 374: 24.67