HitPredict

Interactor 1: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Interactor 2: Q58EY0 (Q58EY0)
RAR related orphan receptor B isoform 1 (RAR-related orphan receptor B) (cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNA)
Gene: RORB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	15604093, 23975195
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1441 Hs			1 459
+	Hs
		723179 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RORA_HUMAN (2-453): 2.48e-115: 350: 61.15
+	Hs
		846416 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RORG_HUMAN (2-454): 9.76e-106: 325: 46.25
+	Hs
		130328 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR5A2_HUMAN (3-446): 6.54e-99: 308: 23.98
+	Hs
		874384 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR1H2_HUMAN (7-453): 2.28e-87: 276: 19.91
+	Mm
		703484 NCOA1_MOUSE (1-1441): 3.4e-149: 493: 92.19		STF1_MOUSE (3-447): 8.31e-91: 285: 21.12
+	Hs
		1030588 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		STF1_HUMAN (3-447): 7.13e-82: 262: 21.55
+	Hs
		509959 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		VDR_HUMAN (3-453): 6.64e-82: 261: 21.44
+	Hs
		265870 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR1I2_HUMAN (8-452): 8.17e-81: 258: 22.72
+	Hs
		1073358 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR6A1_HUMAN (3-424): 1.01e-78: 254: 21.96
+	Mm
		816994 NCOA1_MOUSE (1-1441): 3.4e-149: 493: 92.19		VDR_MOUSE (3-453): 9.62e-83: 263: 21.23
+	Hs
		500364 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RARB_HUMAN (9-138): 6.04e-46: 167: 42.31
+	Hs
		740535 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		PPARG_HUMAN (8-128): 1.04e-45: 167: 46.34
+	Hs
		530798 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RARG_HUMAN (9-84): 1.22e-44: 163: 63.16
+	Hs
		487978 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RARA_HUMAN (9-84): 3.92e-43: 159: 61.84
+	Mm
		509308 NCOA1_MOUSE (1-1441): 3.4e-149: 493: 92.19		RARA_MOUSE (9-84): 6.39e-43: 159: 61.84
+	Hs
		587177 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RXRA_HUMAN (10-91): 4.41e-28: 117: 57.32
+	Hs
		490063 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR2F6_HUMAN (8-85): 1.53e-26: 112: 57.69
+	Hs
		659718 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RXRB_HUMAN (10-90): 5.01e-26: 112: 55.56
+	Hs
		992422 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		PPARA_HUMAN (251-450): 1.74e-17: 86.7: 27.81
+	Hs
		975432 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		PPARD_HUMAN (244-450): 1.28e-15: 80.5: 26.07