HitPredict

Interactor 1: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	15604093, 11500849, 12554772, 11376110, 11014206, 10809226, 14715875, 10731636, 19126643
Identification Methods	two hybrid, fluorescent resonance energy transfer, unspecified method, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1441 Hs			1 530
+	Hs
		369684 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		587177 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		500364 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RARB_HUMAN (49-529): 1.02e-113: 346: 23.92
+	Hs
		510021 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		ERR1_HUMAN (85-497): 1.88e-112: 342: 35.65
+	Hs
		659718 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RXRB_HUMAN (96-498): 2.03e-108: 335: 27.05
+	Hs
		782555 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377354 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		530798 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RARG_HUMAN (68-525): 2.18e-107: 330: 24.18
+	Hs
		914651 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		ERR3_HUMAN (60-499): 2.69e-106: 327: 30.29
+	Hs
		487978 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		1025256 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		874384 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR1H2_HUMAN (49-499): 2.78e-103: 319: 20.86
+	Hs
		611447 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		1055255 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		HNF4G_HUMAN (148-520): 5.7e-102: 314: 24.40
+	Hs
		795598 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		NR4A2_HUMAN (23-501): 3.24e-98: 311: 23.30
+	Mm
		509308 NCOA1_MOUSE (1-1441): 3.4e-149: 493: 92.19		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Mm
		936666 NCOA1_MOUSE (1-1441): 3.4e-149: 493: 92.19		NR1H3_MOUSE (66-499): 7.13e-104: 320: 21.33
+	Hs
		414508 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		437642 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		MCR_HUMAN (141-408): 5.92e-38: 150: 34.03
+	Hs
		487473 NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59