HitPredict

Interactor 1: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Interactor 2: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	20195357
Identification Methods	display technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Hs			1 861
+	Hs
		1078624 SMAD2_HUMAN (1-467): 0: 675: 100.00		ITCH_HUMAN (318-855): 0: 545: 17.83
+	Hs
		808134 SMAD2_HUMAN (1-467): 0: 675: 100.00		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Mm
		1143948 SMAD2_MOUSE (1-467): 0: 675: 99.57		ITCH_MOUSE (318-855): 0: 544: 17.83
+	Hs
		1078667 SMAD2_HUMAN (1-467): 0: 675: 100.00		SMUF2_HUMAN (336-855): 3.41e-177: 531: 20.32
+	Hs
		1078629 SMAD2_HUMAN (1-467): 0: 675: 100.00		NED4L_HUMAN (374-853): 1.61e-171: 524: 19.11
+	Hs
		125487 SMAD2_HUMAN (1-467): 0: 675: 100.00		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		1078654 SMAD2_HUMAN (1-467): 0: 675: 100.00		WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67
+	Hs
		1078671 SMAD2_HUMAN (1-467): 0: 675: 100.00		SMUF1_HUMAN (336-855): 2.1e-167: 506: 17.88
+	Hs
		808087 SMAD3_HUMAN (1-467): 0: 617: 83.94		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Hs
		950248 SMAD3_HUMAN (1-467): 0: 617: 83.94		ITCH_HUMAN (318-855): 0: 545: 17.83
+	Hs
		950287 SMAD3_HUMAN (1-467): 0: 617: 83.94		SMUF2_HUMAN (336-855): 3.41e-177: 531: 20.32
+	Hs
		950249 SMAD3_HUMAN (1-467): 0: 617: 83.94		NED4L_HUMAN (374-853): 1.61e-171: 524: 19.11
+	Hs
		125369 SMAD3_HUMAN (1-467): 0: 617: 83.94		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		950278 SMAD3_HUMAN (1-467): 0: 617: 83.94		WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67
+	Hs
		950291 SMAD3_HUMAN (1-467): 0: 617: 83.94		SMUF1_HUMAN (336-855): 2.1e-167: 506: 17.88
+	Hs
		808240 SMAD5_HUMAN (1-467): 0: 570: 55.45		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Hs
		1305881 SMAD5_HUMAN (1-467): 0: 570: 55.45		WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67
+	Dm
		785516 MAD_DROME (1-467): 0: 586: 55.90		SUDX_DROME (321-855): 1.97e-164: 504: 16.79
+	Xl
		945613 P79947_XENLA (1-467): 0: 571: 55.64		SMUF1_XENLA (362-855): 9.4e-168: 506: 18.89
+	Dm
		785477 MAD_DROME (1-467): 0: 586: 55.90		SMUF1_DROME (466-855): 2.38e-140: 444: 21.43