HitPredict

Interactor 1: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Interactor 2: TAF3 (Q5VWG9)
Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140)
Gene: TAF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27703004, 20195357
Identification Methods	affinity chromatography technology, display technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 929
+	Hs
		1078719 SMAD1_HUMAN (1-467): 0: 565: 55.53		TAF3_HUMAN (1-914): 6.23e-88: 302: 100.00
+	Hs
		1078636 SMAD2_HUMAN (1-467): 0: 675: 100.00		RSF1_HUMAN (161-915): 1.32e-37: 155: 10.46
+	Hs
		171398 SMAD9_HUMAN (1-467): 0: 564: 54.56		PLEC_HUMAN (30-873): 1.38e-72: 265: 10.21
+	Hs
		1078590 SMAD2_HUMAN (1-467): 0: 675: 100.00		KMT2C_HUMAN (147-879): 1.4e-09: 64.4: 8.57
+	Dm
		785451 MAD_DROME (1-467): 0: 586: 55.90		CPN_DROME (180-849): 6.3e-16: 84.7: 10.28
+	Hs
		152653 SMAD1_HUMAN (1-467): 0: 565: 55.53		KMT2D_HUMAN (256-885): 5.06e-11: 69.4: 11.25
+	Hs
		152555 SMAD9_HUMAN (1-467): 0: 564: 54.56		KMT2D_HUMAN (256-885): 5.06e-11: 69.4: 11.25