HitPredict

Interactor 1: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Interactor 2: SMRC2 (Q8TAQ2)
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
Gene: SMARCC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	18003620, 16751102
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 1214
+	Hs
		1078610 SMAD2_HUMAN (1-467): 0: 675: 100.00		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		950225 SMAD3_HUMAN (1-467): 0: 617: 83.94		SMRC2_HUMAN (1-1203): 0: 992: 100.00
+	Hs
		950239 SMAD3_HUMAN (1-467): 0: 617: 83.94		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		160010 SMAD2_HUMAN (1-467): 0: 675: 100.00		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		159959 SMAD3_HUMAN (1-467): 0: 617: 83.94		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		160166 SMAD5_HUMAN (1-467): 0: 570: 55.45		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		160011 SMAD1_HUMAN (1-467): 0: 565: 55.53		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		1078590 SMAD2_HUMAN (1-467): 0: 675: 100.00		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57
+	Hs
		171347 SMAD9_HUMAN (1-467): 0: 564: 54.56		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		950322 SMAD3_HUMAN (1-467): 0: 617: 83.94		ZMIZ1_HUMAN (968-1213): 2.22e-11: 70.8: 16.53
+	Hs
		159987 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		HGS_HUMAN (668-1181): 1.12e-46: 182: 19.20
+	Hs
		232148 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		261498 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Hs
		1035609 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		OGFR_HUMAN (804-1190): 3.3e-13: 76.2: 16.02
+	Hs
		1035630 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		ZMIZ1_HUMAN (968-1213): 2.22e-11: 70.8: 16.53
+	Ce
		107367 DAF3_CAEEL (33-266): 1.14e-42: 163: 28.63		G5EF87_CAEEL (325-1041): 1.19e-88: 306: 34.96