HitPredict

Interactor 1: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Interactor 2: USP9X (Q93008)
Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)
Gene: USP9X

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19135894
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0070410 - co-SMAD binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 2554
+	Hs
		950241 SMAD3_HUMAN (1-467): 0: 617: 83.94		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1078738 SMAD1_HUMAN (1-467): 0: 565: 55.53		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1035531 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		USP9X_HUMAN (1-2554): 0: 3676: 100.00
+	Hs
		1035635 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		UBP24_HUMAN (36-2478): 0: 2211: 29.78
+	Hs
		1078615 SMAD2_HUMAN (1-467): 0: 675: 100.00		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Hs
		950242 SMAD3_HUMAN (1-467): 0: 617: 83.94		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82
+	Hs
		1035532 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		UBP7_HUMAN (1469-2119): 8.05e-96: 339: 18.82