HitPredict

Interactor 1: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	15221015, 15359284, 15946939
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Hs			1 922
+	Hs
		950278 SMAD3_HUMAN (1-467): 0: 617: 83.94		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		1078624 SMAD2_HUMAN (1-467): 0: 675: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Mm
		1143948 SMAD2_MOUSE (1-467): 0: 675: 99.57		ITCH_MOUSE (1-922): 0: 862: 57.54
+	Hs
		1305881 SMAD5_HUMAN (1-467): 0: 570: 55.45		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		125487 SMAD2_HUMAN (1-467): 0: 675: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		950248 SMAD3_HUMAN (1-467): 0: 617: 83.94		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		1078629 SMAD2_HUMAN (1-467): 0: 675: 100.00		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		125369 SMAD3_HUMAN (1-467): 0: 617: 83.94		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		950249 SMAD3_HUMAN (1-467): 0: 617: 83.94		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Dm
		785516 MAD_DROME (1-467): 0: 586: 55.90		SUDX_DROME (14-922): 0: 832: 52.00
+	Hs
		808134 SMAD2_HUMAN (1-467): 0: 675: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		808087 SMAD3_HUMAN (1-467): 0: 617: 83.94		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		808240 SMAD5_HUMAN (1-467): 0: 570: 55.45		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		1078671 SMAD2_HUMAN (1-467): 0: 675: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1078667 SMAD2_HUMAN (1-467): 0: 675: 100.00		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		950291 SMAD3_HUMAN (1-467): 0: 617: 83.94		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		950287 SMAD3_HUMAN (1-467): 0: 617: 83.94		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		1305886 SMAD5_HUMAN (1-467): 0: 570: 55.45		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Dm
		785477 MAD_DROME (1-467): 0: 586: 55.90		SMUF1_DROME (16-538): 1.82e-25: 115: 13.02
+	Xl
		945613 P79947_XENLA (1-467): 0: 571: 55.64		SMUF1_XENLA (314-436): 3.71e-15: 81.8: 22.63