HitPredict

Interactor 1: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0017015 - regulation of transforming growth factor beta receptor signaling pathway GO:0035556 - intracellular signal transduction GO:0046872 - metal ion binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 1088
+	Hs
		681864 SMAD2_HUMAN (1-467): 0: 675: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Rn
		250835 SMAD2_RAT (1-467): 0: 674: 99.36		AKT1_RAT (532-1043): 8.2e-141: 434: 21.97
+	Hs
		681788 SMAD3_HUMAN (1-467): 0: 617: 83.94		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Mm
		682117 SMAD3_MOUSE (1-467): 0: 617: 83.94		AKT1_MOUSE (532-1043): 5.78e-141: 434: 22.16
+	Rn
		812704 SMAD3_RAT (1-467): 0: 617: 83.94		AKT1_RAT (532-1043): 8.2e-141: 434: 21.97
+	Hs
		568627 SMAD3_HUMAN (1-467): 0: 617: 83.94		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		1035175 SMAD2_HUMAN (1-467): 0: 675: 100.00		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		681832 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Rn
		250838 SMAD4_RAT (11-456): 2.52e-150: 441: 31.58		AKT1_RAT (532-1043): 8.2e-141: 434: 21.97
+	Hs
		1035199 SMAD5_HUMAN (1-467): 0: 570: 55.45		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Rn
		291521 SMAD7_RAT (13-443): 2.3e-111: 337: 25.00		AKT1_RAT (532-1043): 8.2e-141: 434: 21.97
+	Hs
		167333 SMAD7_HUMAN (13-443): 2.55e-109: 331: 25.23		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		1035168 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		254477 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90
+	Hs
		1035470 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		MRCKG_HUMAN (656-1009): 3.37e-66: 246: 39.34