HitPredict

Interactor 1: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Interactor 2: MTMR4 (Q9NYA4)
Myotubularin-related protein 4 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Zinc finger FYVE domain-containing protein 11)
Gene: MTMR4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	28675297, 20061380
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046872 - metal ion binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 1195
+	Hs
		950306 SMAD3_HUMAN (1-467): 0: 617: 83.94		MTMR4_HUMAN (1-1195): 0: 1246: 100.00
+	Hs
		1305891 SMAD5_HUMAN (1-467): 0: 570: 55.45		MTMRA_HUMAN (6-625): 2.53e-157: 490: 19.89
+	Hs
		171458 SMAD9_HUMAN (1-467): 0: 564: 54.56		MTMRA_HUMAN (6-625): 2.53e-157: 490: 19.89
+	Hs
		313541 SMAD2_HUMAN (1-467): 0: 675: 100.00		ZFYV9_HUMAN (575-1182): 1.65e-79: 289: 16.34
+	Hs
		313526 SMAD3_HUMAN (1-467): 0: 617: 83.94		ZFYV9_HUMAN (575-1182): 1.65e-79: 289: 16.34
+	Mm
		936613 SMAD1_MOUSE (1-467): 0: 566: 55.42		ZFY16_MOUSE (603-1182): 6.81e-75: 275: 17.30
+	Hs
		313534 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		ZFYV9_HUMAN (575-1182): 1.65e-79: 289: 16.34
+	Hs
		59902 SMAD9_HUMAN (1-467): 0: 564: 54.56		MTMRB_HUMAN (37-262): 6.52e-38: 154: 18.05
+	Hs
		1035486 SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58		ZFY16_HUMAN (1111-1182): 1.7e-12: 74.3: 48.61