HitPredict

Interactor 1: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Interactor 2: MED15 (Q96RN5)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
Gene: MED15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	12167862
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 788
+	Hs
		950253 SMAD3_HUMAN (3-465): 0: 556: 59.66		MED15_HUMAN (1-788): 2.62e-102: 335: 100.00
+	Hs
		1078631 SMAD2_HUMAN (3-465): 0: 541: 55.14		MED15_HUMAN (1-788): 2.62e-102: 335: 100.00
+	Xl
		1155783 Q90YE5_XENLA (3-465): 0: 558: 58.58		MED15_XENLA (7-788): 3.35e-93: 310: 63.04
+	Xl
		1153625 Q6IRR4_XENLA (3-465): 0: 539: 54.94		MED15_XENLA (7-788): 3.35e-93: 310: 63.04
+	Dm
		785517 MAD_DROME (2-465): 0: 594: 72.85		MED15_DROME (9-784): 1.39e-55: 206: 24.72
+	Hs
		1035561 SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28		MED15_HUMAN (1-788): 2.62e-102: 335: 100.00
+	Hs
		160011 SMAD1_HUMAN (1-465): 0: 658: 100.00		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Xl
		1155784 Q9W639_XENLA (13-454): 5.64e-147: 432: 34.09		MED15_XENLA (7-788): 3.35e-93: 310: 63.04
+	Hs
		160166 SMAD5_HUMAN (2-465): 0: 619: 89.46		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		1078735 SMAD1_HUMAN (1-465): 0: 658: 100.00		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		159959 SMAD3_HUMAN (3-465): 0: 556: 59.66		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		160010 SMAD2_HUMAN (3-465): 0: 541: 55.14		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		950234 SMAD3_HUMAN (3-465): 0: 556: 59.66		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		1078605 SMAD2_HUMAN (3-465): 0: 541: 55.14		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		159987 SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		1035526 SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24