HitPredict

Interactor 1: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15221015, 15359284
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 922
+	Hs
		1305881 SMAD5_HUMAN (2-465): 0: 619: 89.46		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		950278 SMAD3_HUMAN (3-465): 0: 556: 59.66		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		950248 SMAD3_HUMAN (3-465): 0: 556: 59.66		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Dm
		785516 MAD_DROME (2-465): 0: 594: 72.85		SUDX_DROME (14-922): 0: 832: 52.00
+	Hs
		125369 SMAD3_HUMAN (3-465): 0: 556: 59.66		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		808135 SMAD1_HUMAN (1-465): 0: 658: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		950249 SMAD3_HUMAN (3-465): 0: 556: 59.66		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808240 SMAD5_HUMAN (2-465): 0: 619: 89.46		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		808087 SMAD3_HUMAN (3-465): 0: 556: 59.66		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		1078761 SMAD1_HUMAN (1-465): 0: 658: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1078760 SMAD1_HUMAN (1-465): 0: 658: 100.00		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Mm
		56826 SMAD1_MOUSE (1-465): 0: 656: 99.14		SMUF2_MOUSE (7-381): 5.96e-31: 132: 16.24
+	Hs
		1305888 SMAD5_HUMAN (2-465): 0: 619: 89.46		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1305886 SMAD5_HUMAN (2-465): 0: 619: 89.46		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Mm
		936618 SMAD1_MOUSE (1-465): 0: 656: 99.14		SMUF1_MOUSE (276-436): 5.09e-16: 84.9: 21.14
+	Xl
		945613 P79947_XENLA (1-465): 0: 649: 94.62		SMUF1_XENLA (314-436): 3.71e-15: 81.8: 22.63
+	Hs
		950291 SMAD3_HUMAN (3-465): 0: 556: 59.66		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Dm
		785477 MAD_DROME (2-465): 0: 594: 72.85		SMUF1_DROME (16-538): 1.82e-25: 115: 13.02
+	Hs
		1305892 SMAD5_HUMAN (2-465): 0: 619: 89.46		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11
+	Hs
		950287 SMAD3_HUMAN (3-465): 0: 556: 59.66		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24