HitPredict

Interactor 1: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Interactor 2: GARE2 (Q75VX8)
GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like)
Gene: GAREM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.439

Property	Details
Experiments	22558309
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1721 Hs			1 874
+	Hs
		1332845 ITSN2_HUMAN (1-1720): 0: 723: 54.73		GARE1_HUMAN (4-874): 0: 651: 40.92
+	Hs
		1176016 ITSN2_HUMAN (1-1720): 0: 723: 54.73		GARE2_HUMAN (1-874): 0: 605: 100.00
+	Hs
		610415 ITSN1_HUMAN (1-1721): 0: 897: 100.00		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Mm
		610656 ITSN1_MOUSE (1-1721): 0: 864: 94.54		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Hs
		203228 ITSN1_HUMAN (1-1721): 0: 897: 100.00		SYNJ1_HUMAN (280-662): 6.77e-09: 61.9: 14.89
+	Hs
		610517 ITSN2_HUMAN (1-1720): 0: 723: 54.73		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Mm
		610657 ITSN2_MOUSE (1-1720): 0: 685: 51.26		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Hs
		1349277 ITSN2_HUMAN (1-1720): 0: 723: 54.73		DAPLE_HUMAN (336-850): 2.01e-09: 63.8: 12.93
+	Hs
		1332846 EP15R_HUMAN (545-929): 2.95e-11: 70.8: 14.14		GARE1_HUMAN (4-874): 0: 651: 40.92
+	Hs
		506515 BCR_HUMAN (732-1682): 1.5e-71: 266: 12.45		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Hs
		610397 ARHG7_HUMAN (1057-1589): 2.33e-69: 253: 15.56		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Hs
		610518 ARHGC_HUMAN (648-1635): 3.19e-67: 253: 15.32		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Ce
		136804 VAV_CAEEL (1160-1566): 7.98e-66: 245: 16.74		UNC89_CAEEL (295-573): 5.72e-10: 65.8: 10.88
+	Mm
		610601 EP15R_MOUSE (183-623): 8.62e-31: 134: 19.46		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Hs
		610308 VAV2_HUMAN (612-1210): 1.5e-14: 81.3: 11.88		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Hs
		610520 EP15R_HUMAN (545-929): 2.95e-11: 70.8: 14.14		CBL_HUMAN (491-829): 7.04e-22: 103: 16.52
+	Mm
		610633 NCK1_MOUSE (889-1057): 2.15e-09: 63.5: 28.49		CBL_MOUSE (446-859): 3.64e-23: 108: 15.24
+	Rn
		1126747 Q5JC29_RAT (529-841): 5.46e-10: 66.6: 12.00		SYNJ1_RAT (316-729): 2.9e-14: 79.6: 11.54
+	Hs
		203230 SH319_HUMAN (1079-1218): 3.12e-09: 63.9: 28.57		SYNJ1_HUMAN (280-662): 6.77e-09: 61.9: 14.89
+	Hs
		203208 NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75		SYNJ1_HUMAN (280-662): 6.77e-09: 61.9: 14.89