HitPredict

Interactor 1: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Interactor 2: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 145 Hs			1 282
+	Dm
		598891 Q9VRL1_DROME (3-143): 4.05e-72: 214: 66.67		SINA_DROME (25-281): 1.57e-109: 321: 81.32
+	Hs
		1216737 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00
+	Hs
		849364 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00
+	Hs
		199099 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		SIAH2_HUMAN (28-282): 1.74e-103: 306: 83.20
+	Hs
		199105 UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06		SIAH2_HUMAN (28-282): 1.74e-103: 306: 83.20
+	At
		1323941 UEV1D_ARATH (2-143): 1.32e-74: 220: 49.30		SINL7_ARATH (37-238): 9.95e-50: 167: 25.73
+	Hs
		1204911 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI50_HUMAN (34-235): 9.68e-46: 162: 19.15
+	Hs
		849360 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI50_HUMAN (34-235): 9.68e-46: 162: 19.15
+	Hs
		919773 UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06		TRI50_HUMAN (34-235): 9.68e-46: 162: 19.15
+	Mm
		895982 UB2D1_MOUSE (10-145): 2.2e-59: 182: 24.82		RNF41_MOUSE (25-152): 1.48e-32: 123: 17.65
+	Hs
		1290204 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		RN125_HUMAN (9-198): 3.5e-31: 117: 18.27
+	Hs
		849405 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		RN125_HUMAN (9-198): 3.5e-31: 117: 18.27
+	Hs
		849318 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRAF3_HUMAN (1-150): 1.22e-25: 107: 15.79
+	Hs
		849427 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRAF4_HUMAN (25-151): 5.73e-26: 107: 20.00
+	Hs
		1377468 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		RN114_HUMAN (22-123): 6.82e-18: 82.1: 26.85
+	Hs
		849499 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		RN114_HUMAN (22-123): 6.82e-18: 82.1: 26.85
+	Hs
		1163056 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRAF7_HUMAN (39-129): 1.38e-11: 66.7: 23.36
+	Hs
		849344 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRAF7_HUMAN (39-129): 1.38e-11: 66.7: 23.36
+	Hs
		919755 UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06		TRAF7_HUMAN (39-129): 1.38e-11: 66.7: 23.36
+	Hs
		919736 UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06		RN151_HUMAN (35-150): 2.56e-11: 64: 26.02