HitPredict

Interactor 1: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 145 Hs			1 336
+	Hs
		1304199 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		849421 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		988038 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		849312 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		1336390 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI39_HUMAN (42-309): 7.63e-48: 170: 16.67
+	Hs
		1285831 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI43_HUMAN (45-303): 1.25e-47: 168: 13.11
+	Hs
		849399 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI43_HUMAN (45-303): 1.25e-47: 168: 13.11
+	Hs
		1313765 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI62_HUMAN (45-334): 1.43e-43: 157: 13.85
+	Hs
		584907 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		RO52_HUMAN (36-286): 4.69e-43: 156: 13.55
+	Hs
		849423 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		849366 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI22_HUMAN (44-318): 2.75e-39: 146: 15.25
+	Hs
		537142 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI27_HUMAN (36-282): 4.98e-37: 141: 16.08
+	Hs
		536760 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI27_HUMAN (36-282): 4.98e-37: 141: 16.08
+	Hs
		1318719 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRIM5_HUMAN (38-285): 1.54e-36: 139: 14.23
+	Hs
		849314 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI26_HUMAN (36-282): 9.9e-36: 137: 17.90
+	Hs
		749252 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		551428 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		RAG1_HUMAN (42-197): 1.72e-29: 121: 20.51
+	Hs
		1290127 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		CHFR_HUMAN (18-224): 6.7e-29: 119: 17.84
+	Hs
		849404 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		CHFR_HUMAN (18-224): 6.7e-29: 119: 17.84
+	Hs
		1261313 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		RN138_HUMAN (34-201): 1.75e-27: 109: 17.06