HitPredict

Interactor 1: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Interactor 2: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 145 Hs			1 493
+	Hs
		1318719 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRIM5_HUMAN (1-493): 3.88e-147: 432: 100.00
+	Hs
		584907 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		RO52_HUMAN (1-492): 6.35e-136: 402: 39.80
+	Hs
		849366 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI22_HUMAN (1-493): 8.67e-130: 387: 50.98
+	Hs
		1336390 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI39_HUMAN (6-492): 6.9e-127: 381: 27.48
+	Hs
		537142 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21
+	Hs
		536760 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21
+	Hs
		135045 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65
+	Hs
		135012 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65
+	Hs
		1377469 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI17_HUMAN (2-492): 1.67e-104: 322: 26.80
+	Hs
		849314 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI26_HUMAN (1-490): 4.61e-103: 320: 25.73
+	Hs
		1285831 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI43_HUMAN (1-480): 2.81e-101: 313: 24.74
+	Hs
		1354526 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI10_HUMAN (1-490): 6.71e-101: 313: 24.60
+	Hs
		1204911 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI50_HUMAN (5-481): 4.35e-98: 306: 24.74
+	Hs
		849360 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI50_HUMAN (5-481): 4.35e-98: 306: 24.74
+	Hs
		849358 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI69_HUMAN (5-492): 6.73e-96: 300: 22.29
+	Hs
		849347 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI72_HUMAN (9-492): 9.25e-96: 299: 21.39
+	Hs
		1313765 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI62_HUMAN (8-488): 7.8e-95: 297: 23.22
+	Hs
		1357712 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI35_HUMAN (2-491): 7.11e-93: 292: 21.40
+	Hs
		1318532 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI31_HUMAN (1-269): 5.66e-40: 150: 31.25
+	Hs
		849384 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI41_HUMAN (1-43): 1.74e-10: 65.4: 39.54