HitPredict

Interactor 1: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17353931
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 145 Hs			1 522
+	Hs
		1377466 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		849315 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		849318 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1052807 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		584907 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		301690 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		537142 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1377469 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI17_HUMAN (58-408): 7.59e-43: 160: 11.86
+	Hs
		536760 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1313765 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI62_HUMAN (63-357): 2.01e-40: 153: 16.17
+	Hs
		1204911 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI50_HUMAN (60-403): 1.01e-39: 152: 14.12
+	Hs
		849314 UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		1318719 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		1318532 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		1377468 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		RN114_HUMAN (63-232): 4.73e-33: 127: 19.13
+	Hs
		1163056 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Mm
		895982 UB2D1_MOUSE (10-145): 2.2e-59: 182: 24.82		RNF41_MOUSE (55-177): 2.68e-17: 84.9: 33.33
+	Hs
		1283434 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		RN166_HUMAN (61-222): 7.37e-16: 79.1: 22.94
+	Hs
		1252560 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Hs
		1290204 UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27		RN125_HUMAN (62-193): 1.59e-11: 66: 25.83