HitPredict

Interactor 1: STK11 (Q15831)
Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)
Gene: STK11

Interactor 2: MARK4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Gene: MARK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	14676191
Identification Methods	affinity chromatography technology, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type	physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	KA1~Pkinase, Pkinase~Pkinase, Pkinase~UBA
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 433 Hs			1 752
+	Mm
		1208616 STK11_MOUSE (1-433): 8.38e-133: 390: 86.93		MARK4_MOUSE (1-752): 0: 731: 97.61
+	Hs
		1079095 STK11_HUMAN (1-433): 8.74e-141: 411: 100.00		MARK2_HUMAN (2-752): 0: 639: 48.15
+	Rn
		139680 MARK2_RAT (1-433): 7.4e-129: 390: 25.00		MARK2_RAT (2-752): 0: 656: 51.71
+	Hs
		1079171 STK11_HUMAN (1-433): 8.74e-141: 411: 100.00		MARK1_HUMAN (1-752): 0: 632: 51.06
+	Hs
		1079163 STK11_HUMAN (1-433): 8.74e-141: 411: 100.00		SNRK_HUMAN (59-603): 9.4e-160: 483: 32.55
+	Hs
		647883 AAPK1_HUMAN (46-314): 3.36e-47: 172: 36.67		MARK3_HUMAN (1-752): 0: 701: 58.56
+	At
		989461 CDPK1_ARATH (2-430): 1.45e-134: 401: 21.14		KIN10_ARATH (58-448): 7.88e-153: 456: 37.12
+	Hs
		883224 STK11_HUMAN (1-433): 8.74e-141: 411: 100.00		SIK1_HUMAN (37-662): 2.63e-142: 438: 33.74
+	Dm
		186259 Q8T9L5_DROME (23-360): 2.57e-142: 419: 61.00		O18645_DROME (32-517): 1.66e-140: 427: 29.45
+	At
		187503 CIPKB_ARATH (29-397): 7.94e-133: 390: 28.57		KIN10_ARATH (58-448): 7.88e-153: 456: 37.12
+	At
		1105318 KIN10_ARATH (33-413): 7.1e-130: 386: 29.06		KIN10_ARATH (58-448): 7.88e-153: 456: 37.12
+	At
		187501 CIPKB_ARATH (29-397): 7.94e-133: 390: 28.57		KIN11_ARATH (58-449): 7.4e-151: 451: 36.18
+	At
		955190 KIN10_ARATH (33-413): 7.1e-130: 386: 29.06		KIN11_ARATH (58-449): 7.4e-151: 451: 36.18
+	At
		249832 CIPK6_ARATH (47-409): 1.05e-127: 378: 25.34		KIN10_ARATH (58-448): 7.88e-153: 456: 37.12
+	Zm
		45132 A0A1D6QH07_MAIZE (38-408): 3.3e-128: 379: 26.62		A0A1D6QH07_MAIZE (47-455): 2.16e-152: 453: 29.91
+	At
		1103380 CIPK3_ARATH (37-391): 4.6e-129: 381: 27.25		CIPK3_ARATH (46-455): 1.79e-150: 447: 29.47
+	At
		1274919 CIPKN_ARATH (20-404): 8.41e-130: 384: 25.26		CIPKN_ARATH (31-440): 9.85e-144: 431: 29.43
+	Hs
		1025158 AAPK1_HUMAN (46-314): 3.36e-47: 172: 36.67		MARK2_HUMAN (2-752): 0: 639: 48.15
+	Hs
		883219 AAPK1_HUMAN (46-314): 3.36e-47: 172: 36.67		SIK1_HUMAN (37-662): 2.63e-142: 438: 33.74