HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	35271311, 18274552
Identification Methods	anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	Histone~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 126
+	Hs
		918277 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		924017 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		924103 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		241495 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		924129 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		924319 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		883009 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83
+	Hs
		918278 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		924315 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		924375 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		924398 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		1079567 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		924107 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		924377 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Dm
		355277 R9PY16_DROME (1-68): 1.24e-24: 94.8: 51.47		H2B_DROME (36-126): 9.49e-47: 148: 95.60