HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: BRAP (Q7Z569)
BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63)
Gene: BRAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23554956
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2, ubiquitin~zf-UBP
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 592
+	Hs
		475079 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		BRAP_HUMAN (1-592): 0: 706: 100.00
+	Hs
		800571 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		UBP5_HUMAN (228-564): 2.66e-63: 225: 15.14
+	Hs
		924439 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		UBP20_HUMAN (296-560): 3.22e-62: 223: 15.75
+	Hs
		474951 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		UBP5_HUMAN (228-564): 2.66e-63: 225: 15.14
+	Dm
		547964 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		Q9VZU7_DROME (255-575): 1.22e-53: 197: 14.84
+	Hs
		1079565 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		UBP13_HUMAN (228-566): 2.87e-53: 197: 12.04
+	Sc
		477617 RL40A_YEAST (1-76): 1.87e-32: 110: 55.26		UBP14_YEAST (273-531): 7.03e-41: 160: 17.90
+	Hs
		924205 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		HDAC6_HUMAN (301-392): 2.71e-31: 131: 24.49
+	Hs
		475219 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		HDAC6_HUMAN (301-392): 2.71e-31: 131: 24.49
+	Hs
		1079619 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		HDAC6_HUMAN (301-392): 2.71e-31: 131: 24.49