HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	25144743, 19615732, 21145461, 34642328, 16503656
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	JAB~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006508 - proteolysis GO:0045116 - protein neddylation
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 334
+	Hs
		130837 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		130838 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		130704 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Sc
		797565 RUB1_YEAST (1-76): 1.45e-21: 81.3: 59.21		RPN11_YEAST (39-333): 9.57e-75: 234: 29.14
+	Hs
		474952 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		BRCC3_HUMAN (56-203): 4.61e-43: 152: 21.23