HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: SENP8 (Q96LD8)
Sentrin-specific protease 8 (EC 3.4.22.-) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8)
Gene: SENP8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.948

Property	Details
Experiments	34642328, 15775960, 30804002, 12759363, 19328766, 15567417
Identification Methods	pull down, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Peptidase_C48~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0006508 - proteolysis
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 212
+	Mm
		669127 NEDD8_MOUSE (1-81): 1.24e-41: 132: 98.77		SENP8_MOUSE (1-212): 5.86e-74: 224: 92.45
+	Hs
		924415 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		SENP2_HUMAN (2-209): 1.69e-67: 218: 17.05
+	Dm
		1177270 NEDD8_DROME (1-76): 2.21e-34: 113: 93.42		Q7JUX2_DROME (2-212): 2.85e-65: 202: 36.49
+	Sp
		141976 UBL1_SCHPO (1-76): 9.64e-30: 102: 81.58		NEP2_SCHPO (3-209): 1.12e-52: 175: 26.51
+	Ce
		1197285 NEDD8_CAEEL (1-77): 7.56e-34: 112: 87.01		Q86FN3_CAEEL (6-212): 1.33e-49: 162: 26.67
+	Sp
		145587 UBL1_SCHPO (1-76): 9.64e-30: 102: 81.58		NESP1_SCHPO (3-212): 3.76e-46: 159: 22.42