HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	28169289
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 757
+	Hs
		924414 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		475196 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		1079607 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		475140 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125347 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Sc
		408371 RS31_YEAST (1-70): 3.03e-30: 105: 52.86		RSP5_YEAST (13-757): 0: 712: 36.40
+	Hs
		125112 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Sp
		145418 RL402_SCHPO (1-76): 6.88e-32: 109: 55.26		PUB3_SCHPO (12-757): 0: 700: 35.23
+	Sp
		145416 RS27A_SCHPO (1-71): 1.02e-29: 104: 53.52		PUB3_SCHPO (12-757): 0: 700: 35.23
+	Sp
		145417 RS27B_SCHPO (1-71): 8.46e-30: 104: 53.52		PUB3_SCHPO (12-757): 0: 700: 35.23
+	Sc
		765382 RUB1_YEAST (1-76): 1.45e-21: 81.3: 59.21		RSP5_YEAST (13-757): 0: 712: 36.40
+	Hs
		474953 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Mm
		924239 RS27A_MOUSE (1-77): 8.65e-37: 122: 57.14		HUWE1_MOUSE (71-756): 8.42e-180: 573: 30.06
+	Hs
		924336 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Hs
		475080 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Sc
		477647 RL40A_YEAST (1-76): 1.87e-32: 110: 55.26		TOM1_YEAST (267-756): 5.63e-161: 518: 33.94
+	Sc
		408448 RS31_YEAST (1-70): 3.03e-30: 105: 52.86		TOM1_YEAST (267-756): 5.63e-161: 518: 33.94
+	Dm
		89880 RL40_DROME (1-76): 1.76e-33: 112: 57.90		D5SHR3_DROME (353-757): 7.18e-175: 510: 42.82
+	Hs
		924156 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94