HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33277362
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UBA~ubiquitin, ubiquitin~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 624
+	Hs
		924208 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		924430 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		924216 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		924435 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Dm
		547958 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Ce
		107538 RL40_CAEEL (1-76): 3.86e-32: 109: 56.58		UBQL_CAEEL (27-621): 1.63e-110: 343: 33.73
+	Zm
		22949 A0A1D6I4G6_MAIZE (2-76): 8.47e-33: 113: 84.00		C0PFA7_MAIZE (40-544): 1.68e-92: 298: 26.19
+	Dm
		81270 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		B7Z0D4_DROME (32-545): 6.97e-60: 218: 14.97
+	Dm
		547961 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		Q9VXF9_DROME (33-313): 1.35e-51: 186: 15.86
+	Dm
		1368389 NEDD8_DROME (1-76): 2.21e-34: 113: 93.42		Q9VXF9_DROME (33-313): 1.35e-51: 186: 15.86
+	Hs
		923945 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Dm
		547946 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Dm
		547898 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		RL40_DROME (33-112): 3.08e-31: 120: 30.86
+	Dm
		1362825 NEDD8_DROME (1-76): 2.21e-34: 113: 93.42		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Dm
		574854 RL40_DROME (1-76): 1.76e-33: 112: 57.90		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Hs
		924263 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		923944 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Bt
		924446 RS27A_BOVIN (1-77): 6.66e-37: 122: 57.14		RS27A_BOVIN (33-119): 4.49e-24: 100: 27.27