HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 81 Hs			1 1024
+	Hs
		924156 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		125347 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		475003 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		983151 Q5U5U6_HUMAN (1-76): 2.4e-30: 107: 57.90		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		125112 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Sc
		477647 RL40A_YEAST (1-76): 1.87e-32: 110: 55.26		TOM1_YEAST (533-1024): 9.89e-156: 513: 26.70
+	Sc
		408448 RS31_YEAST (1-70): 3.03e-30: 105: 52.86		TOM1_YEAST (533-1024): 9.89e-156: 513: 26.70
+	Hs
		474953 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		475140 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		924414 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		SMUF2_HUMAN (648-1024): 5.74e-160: 491: 26.22
+	Hs
		475196 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		SMUF2_HUMAN (648-1024): 5.74e-160: 491: 26.22
+	Hs
		1079607 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		SMUF2_HUMAN (648-1024): 5.74e-160: 491: 26.22
+	Sp
		145418 RL402_SCHPO (1-76): 6.88e-32: 109: 55.26		PUB3_SCHPO (648-1024): 7.14e-157: 485: 26.99
+	Sp
		145416 RS27A_SCHPO (1-71): 1.02e-29: 104: 53.52		PUB3_SCHPO (648-1024): 7.14e-157: 485: 26.99
+	Sp
		145417 RS27B_SCHPO (1-71): 8.46e-30: 104: 53.52		PUB3_SCHPO (648-1024): 7.14e-157: 485: 26.99
+	Sc
		408371 RS31_YEAST (1-70): 3.03e-30: 105: 52.86		RSP5_YEAST (586-1024): 2.86e-156: 484: 23.88
+	Hs
		1079609 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71
+	Dm
		89880 RL40_DROME (1-76): 1.76e-33: 112: 57.90		D5SHR3_DROME (660-1024): 2.2e-152: 460: 28.57
+	Sc
		765382 RUB1_YEAST (1-76): 1.45e-21: 81.3: 59.21		RSP5_YEAST (586-1024): 2.86e-156: 484: 23.88
+	Hs
		924302 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		HERC3_HUMAN (317-460): 3.68e-11: 69.7: 10.88