HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	25332235, 25900982, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	F-box-like~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 542
+	Hs
		1079638 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1079568 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Sc
		408338 RS31_YEAST (1-70): 3.03e-30: 105: 52.86		TAF5_YEAST (240-478): 1.44e-24: 110: 29.26
+	Hs
		903105 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		WDR5_HUMAN (80-265): 5.44e-16: 81.1: 11.92
+	Hs
		903252 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		WDR5_HUMAN (80-265): 5.44e-16: 81.1: 11.92
+	Sc
		759321 RUB1_YEAST (1-76): 1.45e-21: 81.3: 59.21		MET30_YEAST (429-535): 5.29e-19: 92.7: 26.85