HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	30659753
Identification Methods	unspecified method, pull down, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UBA~ubiquitin, ubiquitin~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 589
+	Hs
		924216 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		924435 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		1286323 Q96C32_HUMAN (1-76): 2.04e-29: 107: 57.90		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		924208 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		924430 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Dm
		547958 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		Q9VWD9_DROME (30-582): 3.32e-135: 407: 47.39
+	Ce
		107538 RL40_CAEEL (1-76): 3.86e-32: 109: 56.58		UBQL_CAEEL (31-586): 1.66e-115: 354: 36.30
+	Zm
		22949 A0A1D6I4G6_MAIZE (2-76): 8.47e-33: 113: 84.00		C0PFA7_MAIZE (44-586): 6.17e-109: 339: 29.29
+	Dm
		547961 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		Q9VXF9_DROME (37-317): 4.08e-51: 184: 17.93
+	Dm
		1368389 NEDD8_DROME (1-76): 2.21e-34: 113: 93.42		Q9VXF9_DROME (37-317): 4.08e-51: 184: 17.93
+	Dm
		547941 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		Q9V3W9_DROME (37-394): 1.42e-40: 154: 13.95
+	Pf
		1181547 Q7KQK2_PLAF7 (1-76): 5.8e-29: 107: 59.21		Q8IJS8_PLAF7 (37-351): 6.06e-38: 146: 15.30
+	Hs
		923945 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Dm
		547898 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		RL40_DROME (37-126): 7.82e-34: 126: 29.67
+	Hs
		924263 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Sc
		477610 RL40A_YEAST (1-76): 1.87e-32: 110: 55.26		RAD23_YEAST (45-419): 1.17e-31: 128: 17.73
+	Bt
		924446 RS27A_BOVIN (1-77): 6.66e-37: 122: 57.14		RS27A_BOVIN (37-123): 8.94e-26: 105: 30.68
+	Hs
		923944 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68