HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	25900982, 17318178, 10713156
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, ubiquitination reaction

Property	Details
Interacting Pfam domains	F-box-like~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 605
+	Hs
		1079630 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1079568 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		903105 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		903252 NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Sc
		759321 RUB1_YEAST (1-76): 1.45e-21: 81.3: 59.21		MET30_YEAST (530-604): 1.34e-09: 63.1: 20.00