HitPredict

Interactor 1: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17353931
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 522
+	Hs
		924227 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		475253 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		475011 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Dm
		547968 RS27A_DROME (1-77): 3.39e-36: 121: 57.14		Q9W3I9_DROME (44-500): 2.42e-60: 208: 23.80
+	Hs
		475013 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		923989 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Mm
		924236 RS27A_MOUSE (1-77): 8.65e-37: 122: 57.14		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		301744 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		475134 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Mm
		924253 RL40_MOUSE (1-76): 3.79e-33: 112: 57.90		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Mm
		476671 UBB_MOUSE (1-76): 1.5e-29: 107: 57.90		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		924151 RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		475177 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		924402 RL40_HUMAN (1-76): 3.79e-33: 112: 57.90		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		475125 UBB_HUMAN (1-76): 2.4e-30: 107: 57.90		RN166_HUMAN (61-222): 7.37e-16: 79.1: 22.94