HitPredict

Interactor 1: SCN9A (Q15858)
Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)
Gene: SCN9A

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	unassigned3713
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1988 Hs			1 748
+	Hs
		723851 SCN1A_HUMAN (2-1981): 0: 1938: 75.93		SMUF2_HUMAN (1-748): 0: 834: 100.00
+	Mm
		808358 SCN9A_MOUSE (1-1988): 0: 2013: 92.46		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		69867 SCN2A_MOUSE (2-1988): 0: 2002: 76.55		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		93274 SCN9A_MOUSE (1-1988): 0: 2013: 92.46		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Hs
		1055045 SCN5A_HUMAN (4-1985): 0: 1812: 59.79		SMUF2_HUMAN (1-748): 0: 834: 100.00
+	Mm
		69865 SCN2A_MOUSE (2-1988): 0: 2002: 76.55		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Hs
		723839 SCN1A_HUMAN (2-1981): 0: 1938: 75.93		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Mm
		808381 SCN8A_MOUSE (3-1987): 0: 1836: 69.27		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		808378 SCN5A_MOUSE (4-1985): 0: 1814: 60.39		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		93284 SCN8A_MOUSE (3-1987): 0: 1836: 69.27		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Hs
		808322 SCN8A_HUMAN (3-1987): 0: 1838: 69.61		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Mm
		808363 SCNAA_MOUSE (4-1987): 0: 1761: 53.17		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		93283 SCN5A_MOUSE (4-1985): 0: 1814: 60.39		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Hs
		808128 SCN5A_HUMAN (4-1985): 0: 1812: 59.79		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Mm
		93276 SCNAA_MOUSE (4-1987): 0: 1761: 53.17		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Hs
		808340 SCNAA_HUMAN (4-1983): 0: 1725: 53.92		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		1055040 SCN5A_HUMAN (4-1985): 0: 1812: 59.79		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		125457 SCN5A_HUMAN (4-1985): 0: 1812: 59.79		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Mm
		808349 Q3UF73_MOUSE (2-199): 7.86e-99: 318: 77.78		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		93270 Q3UF73_MOUSE (2-199): 7.86e-99: 318: 77.78		E9PXB7_MOUSE (85-746): 0: 636: 39.39