HitPredict

Interactor 1: EREP1 (Q15884)
Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)
Gene: ENTREP1

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.50	0.417

Property	Details
Experiments	34927784
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 4374
+	Hs
		1079771 EREP1_HUMAN (1-450): 0: 619: 100.00		ITCH_HUMAN (3507-4372): 0: 672: 23.10
+	Hs
		125488 EREP1_HUMAN (1-450): 0: 619: 100.00		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		1079773 EREP1_HUMAN (1-450): 0: 619: 100.00		NED4L_HUMAN (3542-4372): 0: 618: 27.53
+	Hs
		1079783 EREP1_HUMAN (1-450): 0: 619: 100.00		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		808136 EREP1_HUMAN (1-450): 0: 619: 100.00		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Hs
		1079795 EREP1_HUMAN (1-450): 0: 619: 100.00		HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49
+	Hs
		946429 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		ITCH_HUMAN (3507-4372): 0: 672: 23.10
+	Hs
		946430 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		NED4L_HUMAN (3542-4372): 0: 618: 27.53
+	Hs
		946437 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		808086 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46
+	Hs
		946405 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		HECW1_HUMAN (3082-4373): 1.49e-161: 549: 18.31
+	Hs
		125597 Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		946449 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49
+	Hs
		1259694 Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53		WWP1_HUMAN (3507-4372): 0: 613: 22.55