HitPredict

Interactor 1: EREP1 (Q15884)
Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)
Gene: ENTREP1

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	29892012, 25416956, 26186194, 28514442, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 922
+	Hs
		1079771 EREP1_HUMAN (1-450): 0: 619: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125488 EREP1_HUMAN (1-450): 0: 619: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		1079773 EREP1_HUMAN (1-450): 0: 619: 100.00		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808136 EREP1_HUMAN (1-450): 0: 619: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		946437 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		1079753 EREP1_HUMAN (1-450): 0: 619: 100.00		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Hs
		946429 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		1259694 Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		946430 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		125597 Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		808086 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		1079795 EREP1_HUMAN (1-450): 0: 619: 100.00		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11
+	Hs
		946405 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		HECW1_HUMAN (163-530): 4.01e-13: 76.1: 18.40
+	Hs
		946449 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11