HitPredict

Interactor 1: EREP1 (Q15884)
Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)
Gene: ENTREP1

Interactor 2: HECW2 (Q9P2P5)
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
Gene: HECW2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.50	0.632

Property	Details
Experiments	26186194, 28514442, 33961781, 34927784
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 1572
+	Hs
		946449 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		HECW2_HUMAN (1-1572): 0: 1176: 100.00
+	Hs
		946405 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		HECW1_HUMAN (1-1572): 0: 1101: 54.65
+	Hs
		1079753 EREP1_HUMAN (1-450): 0: 619: 100.00		HUWE1_HUMAN (1007-1571): 2.14e-157: 535: 31.55
+	Hs
		125488 EREP1_HUMAN (1-450): 0: 619: 100.00		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		1079773 EREP1_HUMAN (1-450): 0: 619: 100.00		NED4L_HUMAN (664-1033): 5.09e-15: 82.9: 15.47
+	Hs
		1079783 EREP1_HUMAN (1-450): 0: 619: 100.00		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		808136 EREP1_HUMAN (1-450): 0: 619: 100.00		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Hs
		1079771 EREP1_HUMAN (1-450): 0: 619: 100.00		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37
+	Hs
		946430 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		NED4L_HUMAN (664-1033): 5.09e-15: 82.9: 15.47
+	Hs
		946437 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36
+	Hs
		808086 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		NEDD4_HUMAN (262-640): 1.79e-13: 77.9: 10.41
+	Hs
		946429 EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38		ITCH_HUMAN (468-850): 1.52e-10: 68.3: 12.37
+	Hs
		125597 Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53		WWP2_HUMAN (523-857): 7e-16: 85.6: 13.18
+	Hs
		1259694 Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53		WWP1_HUMAN (614-936): 3.01e-14: 80.2: 16.36