HitPredict

Interactor 1: RB11B (Q15907)
Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3)
Gene: RAB11B

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	24056041
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0055038 - recycling endosome membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 577
+	Hs
		914277 RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1287377 RAB1B_HUMAN (4-215): 8.36e-87: 256: 44.81		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Mm
		914516 RB11A_MOUSE (1-218): 1.25e-91: 269: 90.37		OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80
+	Hs
		884562 RAB25_HUMAN (2-218): 1.3e-83: 249: 60.63		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1079980 RB11B_HUMAN (1-218): 2.77e-95: 278: 100.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		914503 RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		914091 RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		914103 RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		914383 RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		148636 RAB1A_HUMAN (1-215): 2.92e-90: 265: 43.26		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		254466 RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22
+	Hs
		149274 RAB1B_HUMAN (4-215): 8.36e-87: 256: 44.81		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		895077 RAB2A_HUMAN (8-178): 5.89e-61: 191: 55.56		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		895213 RAB2A_HUMAN (8-178): 5.89e-61: 191: 55.56		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Hs
		895105 RAB2A_HUMAN (8-178): 5.89e-61: 191: 55.56		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		254463 RAB2A_HUMAN (8-178): 5.89e-61: 191: 55.56		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22