HitPredict

Interactor 1: RB11B (Q15907)
Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3)
Gene: RAB11B

Interactor 2: PI4KB (Q9UBF8)
Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)
Gene: PI4KB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 35844135
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 816
+	Hs
		2059 RB11B_HUMAN (1-218): 2.77e-95: 278: 100.00		A0A0B4J1S8_HUMAN (1-816): 0: 1153: 100.00
+	Mm
		804670 RB11B_MOUSE (1-218): 3.03e-95: 278: 99.08		PI4KB_MOUSE (1-816): 0: 1150: 98.53
+	Hs
		914426 RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37		PI4KB_HUMAN (1-816): 0: 1152: 100.00
+	Dm
		185719 O18335_DROME (1-216): 4.19e-87: 257: 83.80		Q9W0R8_DROME (121-816): 0: 772: 42.44
+	Hs
		914106 RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37		Q4LE69_HUMAN (493-815): 1.05e-111: 377: 34.65
+	Sc
		608954 YPT31_YEAST (1-215): 7.5e-100: 290: 60.09		VPS34_YEAST (463-813): 1.04e-92: 312: 22.63
+	Hs
		787242 RB11B_HUMAN (1-218): 2.77e-95: 278: 100.00		PK3CA_HUMAN (466-813): 9.37e-88: 302: 24.33
+	Sc
		608968 YPT32_YEAST (7-215): 9.32e-87: 257: 60.00		VPS34_YEAST (463-813): 1.04e-92: 312: 22.63
+	Hs
		895109 RAB2A_HUMAN (8-178): 5.89e-61: 191: 55.56		Q4LE69_HUMAN (493-815): 1.05e-111: 377: 34.65
+	At
		1324491 RAA4B_ARATH (9-215): 7.71e-82: 244: 58.45		P4KB1_ARATH (72-632): 9.98e-70: 251: 14.93