HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.588

Property	Details
Experiments	27634302, 23238014
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042752 - regulation of circadian rhythm GO:0048511 - rhythmic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 1140
+	Hs
		1072999 EZH2_HUMAN (1-746): 0: 862: 100.00		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Hs
		203694 SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	At
		955882 CLF_ARATH (248-733): 3.24e-95: 317: 28.36		DDB1A_ARATH (2-1140): 0: 1255: 52.09
+	At
		221822 CLF_ARATH (248-733): 3.24e-95: 317: 28.36		DDB1B_ARATH (3-1140): 0: 1248: 50.92
+	Mm
		93308 SET1A_MOUSE (611-732): 2.47e-18: 92.4: 38.71		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Mm
		93589 SETD2_MOUSE (601-730): 2.36e-17: 89.4: 36.36		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Hs
		1014132 EZH2_HUMAN (1-746): 0: 862: 100.00		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87
+	Sp
		223816 CLR4_SCHPO (330-726): 8.94e-80: 265: 19.09		RIK1_SCHPO (12-1094): 0: 679: 18.91