HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: innatedb

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	24457600, 36517590
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 238
+	Hs
		853908 EZH2_HUMAN (1-746): 0: 862: 100.00		NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42
+	Hs
		432737 EZH2_HUMAN (1-746): 0: 862: 100.00		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		951979 EZH2_HUMAN (1-746): 0: 862: 100.00		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		1031345 EZH2_HUMAN (1-746): 0: 862: 100.00		PABP4_HUMAN (1-95): 5.76e-21: 92.9: 27.00
+	Hs
		992789 EZH2_HUMAN (1-746): 0: 862: 100.00		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		516536 EZH2_HUMAN (1-746): 0: 862: 100.00		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		963528 EZH2_HUMAN (1-746): 0: 862: 100.00		TIAR_HUMAN (5-97): 6.64e-16: 77.8: 25.51
+	Mm
		952203 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		SRSF3_MOUSE (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		1242561 EZH1_HUMAN (15-745): 0: 745: 63.48		RB15B_HUMAN (4-232): 1.77e-31: 123: 22.41
+	Hs
		516645 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Hs
		331871 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		RBM4B_HUMAN (12-89): 4.32e-17: 81: 32.05
+	Sc
		376833 SET2_YEAST (470-733): 1.22e-59: 216: 25.56		PABP_YEAST (7-95): 4.44e-17: 81.7: 22.34