HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: innatedb

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	24457600, 27634302
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 551
+	Hs
		846784 EZH2_HUMAN (1-746): 0: 862: 100.00		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		1080120 EZH2_HUMAN (1-746): 0: 862: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		846983 EZH2_HUMAN (1-746): 0: 862: 100.00		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		1031345 EZH2_HUMAN (1-746): 0: 862: 100.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516536 EZH2_HUMAN (1-746): 0: 862: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1080413 EZH2_HUMAN (1-746): 0: 862: 100.00		OGFR_HUMAN (170-417): 4.4e-09: 61.1: 21.76
+	Hs
		1271101 EZH1_HUMAN (15-745): 0: 745: 63.48		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		1084605 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		846864 NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		847072 NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		516645 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Mm
		1111947 NSD2_MOUSE (275-729): 1.45e-92: 317: 16.03		SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30
+	Sc
		376833 SET2_YEAST (470-733): 1.22e-59: 216: 25.56		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Hs
		846753 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93