HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	24457600, 21078963, 21190999
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~preSET_CXC, Histone~SET
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 136
+	Hs
		934804 EZH2_HUMAN (1-746): 0: 862: 100.00		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		952363 EZH2_HUMAN (1-746): 0: 862: 100.00		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Mm
		952747 EZH2_MOUSE (1-746): 0: 860: 98.39		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Hs
		1080038 EZH2_HUMAN (1-746): 0: 862: 100.00		H3C_HUMAN (1-136): 2.16e-58: 178: 90.44
+	Mm
		952754 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Dm
		356072 EZ_DROME (8-745): 0: 712: 52.70		H3_DROME (1-136): 1.34e-60: 184: 96.32
+	Dm
		356118 ASH1_DROME (196-732): 2.08e-99: 339: 18.55		H3_DROME (1-136): 1.34e-60: 184: 96.32
+	Hs
		331780 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		331823 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00
+	Hs
		331787 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Hs
		331833 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Hs
		935129 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		1086280 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00
+	Hs
		935204 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		1086306 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00
+	Hs
		952555 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Sc
		755791 SET1_YEAST (205-733): 1.13e-84: 292: 16.01		H3_YEAST (1-136): 1.43e-55: 171: 86.03
+	Hs
		331748 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24
+	Hs
		828350 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24
+	Sp
		223811 CLR4_SCHPO (330-726): 8.94e-80: 265: 19.09		H31_SCHPO (1-136): 4.67e-59: 180: 88.97