HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: ARI4B (Q4LE39)
AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)
Gene: ARID4B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Hs			1 1312
+	Hs
		1080299 EZH2_HUMAN (1-746): 0: 862: 100.00		KDM5D_HUMAN (221-690): 3e-87: 314: 15.00
+	Hs
		1080446 EZH2_HUMAN (1-746): 0: 862: 100.00		KDM5B_HUMAN (221-690): 2.14e-74: 274: 15.96
+	Hs
		666533 EZH2_HUMAN (1-746): 0: 862: 100.00		KDM5A_HUMAN (221-690): 1.68e-69: 259: 14.86
+	Hs
		1080261 EZH2_HUMAN (1-746): 0: 862: 100.00		MINT_HUMAN (208-1303): 1.61e-51: 202: 11.51
+	Hs
		1068540 EZH2_HUMAN (1-746): 0: 862: 100.00		PLEC_HUMAN (382-1276): 4.01e-48: 191: 7.91
+	Mm
		1142273 EZH2_MOUSE (1-746): 0: 860: 98.39		ATRX_MOUSE (394-1300): 4.46e-45: 181: 8.49
+	Hs
		146230 EZH2_HUMAN (1-746): 0: 862: 100.00		ARI1A_HUMAN (233-1278): 2.05e-43: 175: 9.26
+	Hs
		802441 EZH2_HUMAN (1-746): 0: 862: 100.00		ATRX_HUMAN (375-1300): 1.37e-41: 170: 10.03
+	Hs
		1080098 EZH2_HUMAN (1-746): 0: 862: 100.00		ARI3B_HUMAN (220-546): 1.61e-41: 163: 17.63
+	Mm
		1149802 Q6AXH7_MOUSE (1-746): 0: 832: 96.41		PLEC_MOUSE (382-1311): 7.39e-47: 187: 9.28
+	Hs
		782374 EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21		KDM5C_HUMAN (222-690): 6.46e-77: 282: 15.34
+	Hs
		331816 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		PLEC_HUMAN (382-1276): 4.01e-48: 191: 7.91
+	Hs
		782389 ASH1L_HUMAN (547-732): 3.87e-57: 214: 30.85		KDM5C_HUMAN (222-690): 6.46e-77: 282: 15.34
+	Hs
		331741 NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03		ATRX_HUMAN (375-1300): 1.37e-41: 170: 10.03
+	Hs
		802480 NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82		ATRX_HUMAN (375-1300): 1.37e-41: 170: 10.03
+	Hs
		802494 SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64		ATRX_HUMAN (375-1300): 1.37e-41: 170: 10.03
+	At
		86054 SUVH6_ARATH (386-733): 2.52e-73: 256: 16.09		ARID6_ARATH (234-526): 1.75e-39: 153: 16.16
+	Hs
		1068676 ASH1L_HUMAN (547-732): 3.87e-57: 214: 30.85		PLEC_HUMAN (382-1276): 4.01e-48: 191: 7.91
+	At
		1012821 SUVH6_ARATH (386-733): 2.52e-73: 256: 16.09		ARID5_ARATH (225-524): 5.71e-34: 138: 15.89
+	Hs
		975294 KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54		TITIN_HUMAN (445-1304): 2.26e-20: 100: 11.53